The standard enclomiphene dosage is 12.5 mg a day, and 25 mg if you are badly suppressed. It is the compound that restarts your brain’s testosterone signal after a cycle, and it does it without the mood swings Clomid is known for. In the book, enclomiphene runs through Chapter 6, Chapter 13 and every protocol in the PCT bonus chapter, so this page puts all of it in one place.
Enclomiphene citrate is a selective estrogen receptor modulator, a SERM. In the book it is the gold standard SERM, the one that restarts your natural testosterone production after a cycle, and the one that raises it in older men without replacing it.
It is also half of a drug you have probably heard of. Clomid, or clomiphene citrate, is a mix of two molecules. Enclomiphene is the active, useful one.
Your brain watches your estrogen level to decide how much testosterone to ask for. So when it sees enough estrogen, it backs off.
Enclomiphene blocks the estrogen receptors in your hypothalamus and pituitary. So your brain reads estrogen as low, and it sends more GnRH, which raises LH and FSH. Then LH tells your testes to make testosterone, while FSH tells them to make sperm.
That last part is what separates it from testosterone replacement. Testosterone gel or injections shut down LH and FSH, and with them, your sperm production. In a phase III trial, men on enclomiphene got their testosterone back to normal and kept their sperm counts, while men on testosterone gel saw their counts drop sharply [2].
Clomid contains about 60 percent enclomiphene and 40 percent zuclomiphene. The two are mirror images of the same molecule, but they act differently.
Enclomiphene does the job, because it blocks estrogen in the brain and raises LH, FSH and testosterone. Zuclomiphene does the opposite of what you want. It acts like an estrogen, and it stays in your body for weeks, building up the longer you take it. That is where Clomid’s side effects come from: mood swings, crying spells, low libido and blurred vision.
| ES | Enclomiphene | Clomid (clomiphene) |
|---|---|---|
| What it is | The pure active isomer | A mix: about 60% enclomiphene, 40% zuclomiphene |
| Effect on testosterone | Raises it | Raises it |
| Estrogen-like side effects | Minimal | Common, from zuclomiphene |
| Mood swings, vision problems | Rare | Known side effects |
| Book’s verdict | First choice | Avoid if you can get enclomiphene |
So the logic is simple: take the half that works and leave out the half that causes the problems. That is why the book calls Clomid a dirty drug.
Below is the full enclomiphene dosage table for every goal, the week-by-week timeline, the maintenance dose, side effects, labs and stacks.
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This page documents Dr. Tony Huge’s research and self-experimentation. It is journalism and education, not medical advice, and it creates no doctor-patient relationship. Dr. Tony Huge holds a Juris Doctor; he is a lawyer, not a physician. Read the full Legal Disclaimer.